Therapy Physics Boards Field Guide

Physics-only rapid review for radiation oncology trainees who have already learned the material and now need fast retrieval under board conditions. Biology is intentionally out of scope.

Legend
A = λN equation or calculation trigger
0.511 MeV number worth memorizing
TG-51 protocol, report, or standard
linac hardware or clinical delivery detail
bold red common board-style trap
Purpose

This is not a textbook. It is a retrieval map: equations, units, assumptions, and the small distinctions that turn a familiar topic into a board question. The writing is intentionally concise and conversational, with mutable protocol and regulatory details checked against public AAPM, NRC, NIST, eCFR, and ICRU reference pages.

Graduating Resident Target

Use this as a cram sheet after first learning the physics. It is optimized for "recognize the question type, choose the governing equation or protocol, avoid the trap, calculate if needed." The densest sections are calculation templates, machine/component logic, QA/protocol tolerances, and brachy/protection rules.

Equation Dashboard

E = hf = hc / λ
Use hc = 1240 eV nm.
A = λN
Activity is disintegrations per second.
T1/2 = 0.693 / λ
Mean life = 1 / λ = 1.44 T1/2.
A(t) = A0e-λt = A0(1/2)n
n = t / T1/2.
I = I0e-μx
HVL = 0.693 / μ; TVL = 2.303 / μ.
Inverse square = (dold / dnew)2
Short SSD makes this unforgiving.
Equivalent square = 4A / P
Use for rectangular field scatter lookup.
DwQ = M kQ ND,w60Co
Core TG-51 relation.
dref,e = 0.6R50 - 0.1 cm
Electron reference depth.
R50 ≈ E0 / 2.33
Electron mean incident energy.
B = P d2 / (WUT)
Primary barrier transmission.
TG-43: Ddot = SKΛGgF / G0
Geometry, radial dose, anisotropy.
BED = nd[1 + d/(α/β)]
Fractionation comparison.
EQD2 = BED / [1 + 2/(α/β)]
Convert to 2 Gy/fx equivalent.

Calculation Playbook

Units, Decay, and Fractionation

Question TypeTemplateSpeed Check
Frequency to wavelength Convert prefix first, then λ = c/f. 3000 MHz = 3 x 109 Hz gives 0.1 m.
Photon energy E = hf = hc/λ. For wavelength in nm, use 1240 eV nm. Energy increases as wavelength decreases.
Activity from atoms Convert half-life to seconds, compute λ = 0.693/T1/2, then A = λN. If T1/2 = 6.93 x 103 s and N = 104, activity = 1 Bq.
Elapsed half-lives fraction remaining = (1/2)t/T1/2. 1, 2, 3, 4 half-lives = 50%, 25%, 12.5%, 6.25%.
Mean life τ = 1/λ = 1.44T1/2. At one mean life, activity is 36.8% of initial.
Effective half-life Teff = TphysTbio/(Tphys + Tbio). Always shorter than both physical and biologic half-life.
Fractionation comparison BED = nd[1 + d/(α/β)], then EQD2 = BED/[1 + 2/(α/β)]. Late-effect tissues use low α/β values; higher dose per fraction matters more.
Nuclear reaction balancing Conserve total A and total Z on both sides. Do A first, then Z. It prevents isotope-choice guessing.

Beam Geometry and Monitor Units

Question TypeTemplateFast Trap Check
SSD/PDD MU MU = Rx / [O ScSpWF TF OAR (PDD/100) ISF]. PDD table means SSD geometry. Use field size at patient for Sp.
SAD/TMR MU MU = Rx / [O ScSpWF TF OAR TMR]. Parallel-opposed equally weighted beams: divide Rx by 2 before MU per beam.
Depth-dose transfer If MU/geometry is unchanged, dose ratio between depths equals PDD or TMR ratio at those depths. For same SSD beam, D3/D6 = PDD3/PDD6.
Equivalent square eq square = 4A/P = 2ab/(a+b) for rectangle. Use collimator equivalent square for Sc; blocked/MLC field for Sp.
Wedge angle θwedge = 90 - hinge/2. Hinge 135 degrees -> 22.5 degree wedge.
Gap for matching fields gap = d(L1/SSD1 + L2/SSD2)/2. Use half-field length from central axis to match line. Half-beam block has no divergence on blocked side.
Radiologic depth drad = Σ ρrelt. Low-density lung reduces water-equivalent depth; bone increases it.

Shielding and Source Timing

Question TypeTemplateFast Trap Check
HVL/TVLHVL = 0.693/μ; TVL = 2.303/μ; n = log10(I0/I).Each TVL reduces intensity by 10x, not by 90% of original repeatedly in linear units.
Primary barrierB = Pd2/(WUT).Uncontrolled area design goal is much lower than controlled area.
IMRT leakage workloadWL = C W, commonly C = 2-10.More MU means more leakage workload.
HDR decay correctiontnow = tnominalSnominal/Snow.If the source has decayed, treatment time gets longer.
Permanent implant total doseTotal dose is proportional to initial dose rate x mean life, D ∝ R0.Shorter half-life needs higher initial dose rate for same total dose.
Transit doseMore source travel events -> more transit contribution.For same total dose, more HDR fractions usually means more transit dose.

Most questions are not asking for a fact in isolation. They tie two pieces of information together: a unit plus its base dimension, a machine component plus what changes in electron mode, a formula plus the condition under which it is valid, or a protocol plus what it does not cover.

Default board behavior: identify the quantity, check units, check geometry, check energy range, then ask whether the word "EXCEPT" flipped the task. If the question contains a table, decide first whether it is an SSD/PDD problem or an SAD/TMR problem.

Question StyleFast ResponseCommon Trap
Derived SI unitGy, Sv, J, N, Bq are derived; kg is base.Confusing named SI units with base SI units.
Changes with filtrationHVL and effective energy increase; intensity decreases; max energy unchanged.Thinking filtration increases kVp.
Electron mode on linacTarget out, flattening filter out, scattering foil or scanning in, applicator in, monitor chamber still used.Removing the monitor chamber.
Short SSD superficial x-raysInverse square sensitivity is huge.Blaming air attenuation first.
Orthovoltage vs MVBone dose rises with kV because photoelectric effect is Z-sensitive.Applying MV Compton logic to kV beams.

Trap Decoder Library

If The Question Mentions...Think FirstLikely Answer Direction
"EXCEPT"Underline the negation.The right answer is the non-member, not the most familiar true statement.
SI unitsBase vs derived.kg, m, s, A, K, mol, cd are base; Gy/Sv/J/N/Bq are derived.
Inelastic collisionConserved quantity.Momentum conserved; kinetic energy not necessarily conserved.
Cyclotron energy limitRelativistic mass/phase mismatch.At high velocity, particle no longer stays synchronized with fixed RF.
Filtered kV beamBeam hardening.HVL/effective energy up, intensity down, max energy unchanged.
Gamma Knife in brainCo-60 energy in soft tissue.Compton dominates.
18 MV photonsPhotonuclear threshold.Neutron dose is a concern.
SF6 in waveguideInsulation/dielectric strength.Do not choose cooling or acceleration.
TLD vs OSLDReadout stimulus.TLD = heat; OSLD = light.
Rounded MLC leaf endConsistent penumbra plus dosimetric leaf gap.Do not confuse DLG with physical leaf gap alone.
Annual SRS/SBRT end-to-endMeasured vs calculated dose tolerance.Think 5% for end-to-end dosimetric agreement.
Patient release after implant/unsealed sourcePublic exposure from released patient.Release if another individual unlikely to exceed 5 mSv TEDE.
Proton range questionHU-to-stopping-power and beam-direction uncertainty.Range margin is not a uniform isotropic PTV expansion.
DICOM object listRTPLAN/RTSTRUCT/RTDOSE/RTIMAGE/REG/waveforms.Machine log file is the non-DICOM-style answer.

Unit Sense and Constants

QuantityBoard ValueUse
Speed of light3.00 x 108 m/sc = fλ
Planck relationE = hf = hc/λhc = 1240 eV nm
Electron rest energy0.511 MeVPair production threshold = 1.022 MeV.
Proton/electron mass ratio1836Proton is about 1800 times electron mass.
Atomic mass unit931.5 MeV/c2Mass defect to binding energy.
Avogadro6.022 x 1023 mol-1Atoms per mole.
Curie3.7 x 1010 BqOld activity unit.
Roentgen2.58 x 10-4 C/kg airExposure for photons in air; 1 R ~ 0.876 cGy in air.
Gray1 J/kgAbsorbed dose.
SievertGy x weighting factorsProtection quantity, not tumor prescription dose.

Base vs Derived SI Units

Base SIDerived / Named SIPhysics Board Translation
meter (m), kilogram (kg), second (s)newton, joule, grayN = kg m s-2; J = N m; Gy = J kg-1.
ampere (A), kelvin (K), mole (mol), candela (cd)coulomb, volt, becquerel, sievertBq = s-1; Sv = J kg-1 after weighting factors.

Mechanics and Accelerator One-Liners

  • Inelastic collision: momentum is conserved; kinetic energy is not. If the bodies stick together, it is perfectly inelastic.
  • Work-energy: W = Fd cosθ and KE = 1/2 mv2 for nonrelativistic particles.
  • Relativistic energy: E2 = (pc)2 + (m0c2)2; for photons, E = pc.
  • Cyclotron limit: fixed-frequency cyclotrons lose synchrony at relativistic speeds because effective mass increases; synchrocyclotrons vary RF frequency to compensate.
  • Synchrotron: magnetic field and RF frequency are varied so particles stay in a fixed orbit while energy increases.

Atomic and Nuclear Bookkeeping

  • Atomic number Z is protons; mass number A is nucleons; neutrons = A - Z.
  • Isotopes share protons, isobars share A, isotones share neutrons. Memory: P-A-N.
  • Shell capacity = 2n2. K shell has 2, L has 8, M has 18.
  • Characteristic x-rays occur when an outer-shell electron fills an inner-shell vacancy. Auger electrons are the competing non-radiative route.
  • Binding energy per nucleon peaks near iron. Fission of heavy nuclei and fusion of light nuclei both move toward higher binding energy per nucleon.
Board check: A photon has frequency 3000 MHz. What is the wavelength?

Convert first: 3000 MHz = 3 x 109 Hz. Then λ = c/f = 3 x 108 / 3 x 109 = 0.1 m. The trap is failing to move MHz to Hz.

Board check: Which particle can have a bremsstrahlung interaction?

Any charged particle can radiate bremsstrahlung when accelerated/decelerated in a Coulomb field. In practice, electrons and positrons matter most because radiative losses scale inversely with particle mass squared. Neutrons, photons, and neutrinos are not the classic charged-particle bremsstrahlung answer.

Decay Mode Signatures

ModeSignatureBoard Memory
Beta-minusn → p + e- + anti-ν; A same, Z increases by 1Neutron-rich nucleus moves up in Z.
Beta-plusp → n + e+ + ν; A same, Z decreases by 1Needs at least 1.022 MeV for positron creation.
Electron capturep + e- → n + ν; A same, Z decreases by 1Produces characteristic x-rays/Auger electrons from shell vacancy.
AlphaA decreases by 4, Z decreases by 2Heavy nuclei; discrete alpha energies.
GammaNo A or Z changeNuclear de-excitation.
Internal conversionNo A or Z change; orbital electron ejectedCompetes with gamma emission.

Decay Diagrams Without Panic

  • Vertical transition on a decay scheme = nuclear de-excitation, usually gamma or internal conversion.
  • Beta spectra are continuous because energy is shared with a neutrino/antineutrino.
  • Alpha and gamma emissions are discrete-energy processes in simple diagrams.
  • Electron capture and internal conversion both produce atomic vacancies, so both can lead to characteristic x-rays or Auger electrons. The nuclear change is different.
  • Positron annihilation produces two 0.511 MeV photons traveling nearly 180 degrees apart after the positron slows.

Activity Math

  • A = λN. If you know atoms and half-life, convert half-life to seconds, compute λ, then activity in Bq.
  • A(t)=A0(1/2)t/T1/2. Count half-lives when possible; it is faster and safer than logs.
  • Rule of 72: approximate percent decay per unit time = 72 / T1/2 when the half-life is in that unit.
  • Teff = (TphysTbio) / (Tphys + Tbio). Effective half-life is always shorter than either component.
  • Total decays from a source = A0 / λ. Permanent implant total dose is proportional to initial dose rate divided by λ.

Parent-Daughter Equilibrium

Parent vs DaughterNameWhat Happens
Parent half-life much longer than daughterSecularDaughter activity grows until it approximately equals parent activity.
Parent longer, but not enormously longerTransientDaughter rises, peaks, then appears to decay with parent; daughter can exceed parent.
Parent shorter than daughterNo useful equilibriumParent disappears before sustaining daughter.

Exam trap: gamma emission and internal conversion compete with each other. Beta-minus and beta-plus do not "compete" in the same nucleus in the same simple way; they reflect opposite N/Z pressures.

Generator and Activation Logic

  • A useful generator has a parent long enough to ship/use and a daughter short enough to grow in quickly.
  • For neutron activation, add the incident particle to the target nucleus and conserve A/Z after emitted particles leave.
  • Specific activity increases as half-life decreases for the same number of radioactive atoms because A = λN.

Charged Particle Logic

  • Stopping power is energy loss per path length. Collision stopping makes ionization/excitation; radiative stopping makes bremsstrahlung.
  • Collision stopping roughly increases with z2/v2. Doubling particle charge matters more than doubling mass.
  • Bremsstrahlung yield rises with particle energy and absorber Z, and is far more important for electrons than heavy charged particles.
  • LET is local energy deposition density. High LET generally means dense ionization, higher RBE, and lower OER, but clinical protons are still assigned RBE 1.1 in standard planning.
  • Electron multiple scattering is why electron fields spread laterally and why small cutouts lose lateral charged particle equilibrium.
ParticleDominant Exam PhysicsClinical/Shielding Memory
ElectronMultiple Coulomb scattering, collision + radiative stopping.Finite practical range, broad penumbra with depth, bremsstrahlung tail.
ProtonCollision stopping, Bragg peak, nuclear interactions.Range uncertainty and distal edge sensitivity.
AlphaHigh charge, high LET, short range.Dangerous internally, stopped by very thin external shielding.
NeutronIndirectly ionizing; elastic/inelastic scatter and capture.Hydrogenous moderation, capture gammas, high radiation weighting factor.

Photon Interaction Logic

InteractionWhere It MattersHigh-Yield Consequence
Coherent/RayleighLow energy, high ZNo energy transfer to matter; contributes to scatter blur in imaging.
PhotoelectrickV range, high ZStrong Z dependence; bone and iodine stand out.
ComptonTherapy MV range in soft tissueDepends mainly on electron density, not Z. Dominant for Co-60/Gamma Knife in brain.
Pair production> 1.022 MeV, rises with energy and ZProduces positron/electron pair; annihilation photons after positron slows.
PhotonuclearHigh-energy linac photons, especially >10 MVNeutron production concern for 15/18 MV beams.

I = I0e-μx is narrow-beam attenuation. Broad-beam geometry adds scatter back into the detector, so apparent attenuation is less severe. HVL hardens a polyenergetic beam because low-energy photons are preferentially removed.

InteractionApproximate DependenceAnswer Shortcut
PhotoelectricRoughly Z3/E3Dominates kV contrast and bone dose.
ComptonElectron density, weak Z dependenceDominates MV soft-tissue therapy dose.
Pair productionThreshold 1.022 MeV, rises with Z and energyRelevant above threshold, more with high-energy beams/high-Z materials.
PhotonuclearHigh-energy photons interacting with nucleusNeutrons from high-MV treatment heads.
Board check: For a soft-tissue head target, why does Gamma Knife dose deposition mainly follow Compton physics?

Co-60 emits about 1.17 and 1.33 MeV photons, average about 1.25 MeV. In soft tissue at those energies, Compton dominates.

Neutron and Proton Logic

  • Fast neutrons lose energy most efficiently in hydrogen-rich material through elastic scattering; slow neutrons are more likely captured.
  • Neutron protection needs hydrogenous moderation plus capture shielding. For high-energy photon vaults, maze design and door composition matter.
  • Protons have finite range and a Bragg peak. The distal edge is biologically and geometrically sensitive, so avoid placing it in a critical serial OAR when possible.
  • Range uncertainty comes from CT number to stopping-power conversion, setup/anatomy changes, and motion. Robust optimization is not optional thinking in proton planning.

Kilovoltage Tube Logic

  • Thermionic emission releases electrons from the cathode. Tube current controls photon quantity; kVp controls spectrum endpoint and beam quality.
  • λmin = hc/eV. Maximum photon energy equals electron kinetic energy; filtration does not change that endpoint.
  • Filtration removes low-energy photons, increasing HVL/effective energy and decreasing intensity.
  • Anode angle increase makes the effective focal spot larger, improves field coverage, reduces heel effect severity, and worsens spatial resolution.
  • The oil bath removes heat and provides electrical insulation.
  • Tungsten K-characteristic x-rays need incident electrons above the K-shell binding energy; K lines are roughly 59 and 67 keV.
Parameter ChangeWhat IncreasesWhat Does Not Increase
Increase mAPhoton fluence/output, heatEndpoint energy, effective energy
Increase kVpEndpoint energy, effective energy, output, penetrationTube current
Add filtrationHVL, effective energy, mean energyMaximum photon energy
Increase anode angleEffective focal spot size, field coverageSpatial resolution, heel effect severity
Decrease focal spotSpatial resolutionHeat capacity

Linac Head and RF Chain

ComponentBoard RoleTrap
MagnetronGenerates microwaves directly; common in lower-energy machines.Not an amplifier.
KlystronAmplifies RF from a low-power source.Does not generate microwaves from scratch.
ThyratronHigh-speed switch/controlled rectifier for pulsed power.Not the voltage step-up transformer.
WaveguideAccelerates electrons with RF fields; standing or traveling wave.Transmission waveguide carries RF to accelerator structure.
SF6 gasInsulates high-voltage/RF waveguide components because of high dielectric strength.Not a coolant and not the accelerating medium.
Bending magnetDirects electrons from accelerator to target/foil; energy analyzes/focuses.Acts on electrons, not produced photons.
TargetBremsstrahlung photon production.Removed for electron mode.
Flattening filterFlattens forward-peaked photon beam at a specified depth.Removed in FFF and electron mode.
Scattering foilBroadens electron beam.Not used in photon mode.
Monitor chamberTerminates dose by MU; checks symmetry/flatness.Still present in electron mode.

Treatment Machine Family Tree

MachineWhat It Accelerates/UsesExam Hook
Linear acceleratorElectrons accelerated in a straight waveguidePhoton mode uses target; electron mode removes target.
BetatronElectrons induced by changing magnetic fluxCan produce electrons or photons with a target; mostly historical.
MicrotronElectrons recirculated through RF cavityEnergy gain per pass with magnetic recirculation.
CyclotronCharged particles in spiral path, fixed magnetic fieldRelativistic mass/velocity limits classic fixed-frequency design.
SynchrotronCharged particles in fixed ringMagnetic field and RF vary with particle energy.
Gamma KnifeMany Co-60 sourcesCo-60 average photon energy about 1.25 MeV.
TomotherapyHelical fan-beam 6 MV linacBinary MLC, no flattening filter profile.
CyberKnifeRobotic compact linacNon-isocentric beams, image guidance, often cones/MLC.

Collimation, MLC, and FFF

  • Modern MLC transmission is typically 1-3%. Interleaf leakage is between leaves; intraleaf leakage is through a leaf; tongue-and-groove reduces leakage but can make a narrow underdose band.
  • Dynamic MLC delivery is more sensitive to systematic leaf-position errors than static shaping. A 1 mm systematic error can matter.
  • FFF removes the flattening filter: dose rate rises, head scatter falls, out-of-field dose falls, spectrum softens, and the profile is peaked rather than flat.
  • FFF does not magically mean "higher energy." A nominal 6X FFF beam is often less penetrating than flattened 6X.
  • Rounded MLC leaf ends make penumbra more consistent as leaves move across the divergent beam. The price is partial transmission through the rounded tip, modeled with the dosimetric leaf gap.

MLC Error Language

TermMeaningWhy It Is Tested
Dosimetric leaf gapModeling parameter for rounded leaf-end transmission and geometry.Small gap errors can bias IMRT/VMAT dose.
Tongue-and-grooveInterlocking leaf design to reduce interleaf leakage.Can cause narrow underdose if adjacent leaves expose a region sequentially.
Interleaf leakageLeakage between adjacent leaves.Important with high MU treatments.
Intraleaf transmissionTransmission through the leaf body.Typical modern value around 1-3%.
Leaf positioning accuracyActual leaf vs planned leaf location.Systematic errors matter more than isolated random errors.

Quantity Decoder

QuantityDefinitionDo Not Confuse With
FluenceParticles crossing a sphere per cross-sectional area.Planar fluence through a flat plane.
Energy fluenceRadiant energy per area; for monoenergetic beam = fluence x energy.Fluence rate.
KermaKinetic energy released per unit mass.Dose, unless charged particle equilibrium holds.
Absorbed doseEnergy deposited per unit mass.Equivalent/effective dose in Sv.
ExposureIonization in air from photons.Not defined for electrons/protons or in tissue.

Detector Choice

  • Ion chambers are the reference workhorse: stable, near tissue equivalent after corrections, and NIST-traceable through calibration coefficients.
  • Diodes are sensitive to energy, temperature, field size, dose rate history, and angle. They are not meaningfully pressure-dependent like air chambers.
  • TLDs are read by heat. OSLDs are read by light. Radiochromic film is near tissue equivalent and self-developing; use net optical density.
  • Modern EPIDs are usually indirect detectors: scintillator plus photodiode array, commonly amorphous silicon.
  • Free-air ion chambers are standards-lab devices, not the usual meter for vault barrier surveys.
DetectorStrengthBoard Weakness / Correction
Farmer chamberReference calibration in broad fieldsVolume averaging in small fields/high gradients.
Parallel-plate chamberElectron dosimetry, buildup/surface regionGuard ring, polarity, and calibration details matter.
DiodeHigh sensitivity, small fieldsEnergy, temperature, angular, dose-rate, and field-size dependence.
DiamondNear tissue equivalent, small field utilityDetector-specific correction factors still needed.
FilmHigh spatial resolution planar doseScanner, orientation, calibration curve, net optical density.
Ion chamber survey meterBarrier photon dose-rate surveysUse appropriate energy range and pulsed-field response.
GM meterContamination/presence checksPoor quantitative therapy barrier meter.

Reference Calibration

TG-51 is an absorbed-dose-to-water protocol for Co-60, MV photons, and electrons. It is not a brachytherapy source-strength protocol for Ir-192.

ItemPhotonElectron
Reference field10 x 10 cm2Usually cone/applicator field with adequate size for energy
Reference depth10 cm water-equivalent depthdref = 0.6R50 - 0.1 cm
Beam quality%dd(10)xR50
Core correctionkQkQ plus gradient/replacement conventions
Corrected readingM = MrawPTPPionPpolPelec plus local leakage/timing corrections if needed.
ADCL calibration cycleIon chamber/electrometer calibration is usually kept on a 2-year cycle; annual machine output calibration is a separate clinic QA item.

Electron depth-ionization conversion: for I50 in cm, R50 = 1.029I50 - 0.06 for I50 <= 10 cm, and R50 = 1.059I50 - 0.37 for I50 > 10 cm. Mean incident electron energy is E0 = 2.33R50.

TG-51 Correction Factor Triggers

CorrectionCorrects ForMemory Hook
PTPTemperature/pressure effect on air densityOpen-to-air ion chamber reading changes with weather.
PionIon recombinationMore important for pulsed/high-dose-per-pulse beams.
PpolPolarity effectCompare readings at opposite bias polarity.
PelecElectrometer calibrationChamber-electrometer system factor.
kQBeam quality conversion from Co-60 calibration qualityPhoton quality uses %dd(10)x; electron quality uses R50.

Saturation curve logic: in the saturation region, collected charge should be nearly independent of bias voltage. If increasing voltage still meaningfully increases reading, recombination is not negligible. Pulsed beams need two-voltage or equivalent recombination correction discipline.

Depth-Dose and Scatter

FactorMeaningBoard Directionality
PDDDose at depth divided by dose at dmax for same SSD setup.Increases with energy, SSD, and field size; decreases with depth.
TMRDose at depth divided by dose at dmax with detector points at same source distance.Independent of SSD; used for SAD/isocentric calcs.
ScCollimator/head scatter.Depends on collimator setting.
SpPhantom scatter.Depends on field size at phantom/patient.
ScpTotal output factor.Measured in phantom; often split into ScSp.
OAROff-axis ratio.Profile change relative to central axis, not organ-at-risk in physics tables.

Percent Depth Dose Directionality

ChangePDD EffectWhy
Increase beam energyIncreases PDD, deeper dmaxMore penetrating beam.
Increase field sizeIncreases PDDMore phantom scatter contributes dose at depth.
Increase SSDIncreases PDDInverse square difference between dmax and depth is reduced.
Increase depthDecreases PDD after dmaxAttenuation and inverse square dominate.
Add low-density lung in pathCan reduce attenuation but perturb electron equilibriumSimple equivalent path length can fail near interfaces.

PDD to TMR approximation: conceptually remove the SSD inverse-square effect from PDD. A common working form is TMR(d,rd) approx PDD(d,r,SSD)/100 x [(SSD+d)/(SSD+dmax)]2 x [Sp(rdmax)/Sp(rd)]. On a board problem, the point is usually directionality: TMR is an SAD quantity and is not the same thing as PDD/100.

Monitor Unit Patterns

First branch: SSD question uses PDD. SAD/isocenter question uses TMR/TPR. If the table hands you PDD and says 100 cm SSD, do not use TMR because it feels more modern.

SetupSkeletonNotes
SSDMU = Rx / [O x Sc x Sp x modifiers x PDD/100 x ISF]ISF corrects from calibration geometry to treatment point geometry.
SADMU = Rx / [O x Sc x Sp x modifiers x TMR]Use dose per beam if fields are equally weighted.
Wedge pairwedge angle = 90 - hinge angle/2Hinge 135 degrees -> wedge 22.5 degrees.
Radiologic path∑ density x thickness3 cm lung at density 0.25 behaves like 0.75 cm water-equivalent path.
Field gapgap ~ d(L1/SSD1 + L2/SSD2)/2Half-beam block removes divergence on that side.

Dose Perturbation and Out-of-Field Rules

SituationFast AnswerTrap
Carbon-fiber couch in beamAttenuates the beam; if unmodeled, delivered dose at target can be low for beams through couch.It is a dosimetric effect, not just a collision issue.
Bone/high-Z interfaceCan increase dose near entrance side from backscatter and perturb dose around exit side.Direction and magnitude depend on energy, material, and geometry.
Metal implantCauses CT artifact and dose perturbation; overrides/model-based algorithms help but do not remove uncertainty.High density on CT is not automatically accurate material assignment.
Out-of-field near targetMostly patient/internal scatter.Shielding only at the head will not remove near-field patient scatter.
Out-of-field far from targetHead leakage and collimator scatter become relatively more important.High-MU IMRT/VMAT can increase leakage contribution.

Special Beam Rules

BeamRulesTraps
ElectronsRp ~ E/2, R90 ~ E/3.2, practical treatment depth ~ E/3.Surface dose increases with energy. Small cutouts, obliquity, and low energy can change PDD.
Electron field sizeNeed lateral scatter equilibrium; small fields reduce output and alter depth dose.Cutout factor is not just area.
BolusRaises surface dose and shifts depth-dose curve toward surface.Bolus does not increase penetration.
ProtonsFinite range, Bragg peak, SOBP, RBE convention 1.1.Distal edge has high LET/range uncertainty; motion interplay matters in PBS.
TBISpoiler increases surface dose; lung blocks reduce lung dose.Long SSD lowers dose rate; AP/PA may be easier for weak patients.
TSEILarge SSD, multiple fields/poses, high surface dose.Soles, scalp, perineum, and skin folds need attention.

Electron Clinical Rules

  • Approximate therapeutic range: R90 ~ E/3.2; practical range: Rp ~ E/2.
  • Minimum field dimension should generally exceed practical range for stable output/depth dose.
  • Obliquity increases surface dose and shifts dose proximally; it also broadens penumbra.
  • Air gaps reduce output and alter effective SSD; extended SSD corrections are electron-specific, not simple photon inverse square alone.
  • High-Z shielding in electron fields can make bremsstrahlung; use appropriate thickness and consider low-Z bolus/covering material near skin.

Proton Board Rules

ConceptHigh-Yield RuleTrap
RBEClinical proton plans conventionally use RBE 1.1; photons/electrons use 1.0.Carbon ion RBE is variable and model-dependent.
RangeRange is dominated by proton energy and patient stopping power. A 200 MeV proton has range on the order of 26 cm in water.HU-to-stopping-power calibration drives range uncertainty.
Range uncertaintyCommon mental model: distal/proximal margin includes a percent of range plus setup.Range margin is along the beam direction, not a uniform 3D shell.
SOBP modulationWider modulation adds lower-energy components and generally increases entrance dose.There is no photon-like buildup region for protons.
Lateral penumbraAperture systems can be sharp near surface, but multiple Coulomb scattering broadens penumbra with depth.Distal edge and lateral edge are different uncertainty problems.
PBS interplaySpot scanning plus moving anatomy can create hot/cold interplay.Repainting, gating, compression, and robust optimization are mitigation tools.

TG-142 Linac QA Values To Know

CadenceTestTolerance
DailyPhoton output constancy3%
Daily/weeklyElectron output constancy3%; daily for machines with unique electron monitoring needs.
DailyLasersNon-IMRT 2 mm; IMRT 1.5 mm; SRS/SBRT 1 mm.
DailyODI2 mm conventional/IMRT; 1 mm SRS/SBRT.
MonthlyPhoton/electron output and backup monitor chamber2%
MonthlyLight-radiation coincidence, symmetric jaws2 mm or 1% per side.
MonthlyDynamic MLC leaf positioningAbout 1 mm; static positioning about 2 mm.
AnnualTG-51 output calibration1% from baseline/expected.
AnnualFlatness/symmetry baseline change1%
SRSOverall localization/delivery accuracy1 mm is the board number.

Protocol Index: What Each Report Is For

Protocol / ReportUseClassic Exam Association
TG-51Reference absorbed dose to water calibrationkQ, %dd(10)x, R50.
TG-142Medical accelerator QADaily 3%, monthly 2%, SRS tighter geometry.
TG-43Brachytherapy dose calculation formalismAir-kerma strength, dose-rate constant, g(r), F(r,θ).
TG-56Brachytherapy QAHDR source strength and positional checks.
TG-66CT simulator QALaser/imaging plane/table alignment.
TG-100Risk-based quality managementFMEA, process maps, fault trees, quality management by risk.
TG-101SBRT recommendationsSteep gradients, image guidance, normal tissue constraints.
TG-119IMRT commissioning test casesBenchmarking planning/delivery accuracy.
TG-135Robotic radiosurgery QACyberKnife-style delivery systems.
TG-203Cardiac implantable electronic devicesRisk stratification by dose, pacing dependence, neutrons.
TG-218IMRT measurement-based patient-specific QA3%/2 mm, 95% tolerance, 90% action.
TG-224Proton machine QARange, spot position, output, imaging/safety checks.
TG-302Surface-guided radiotherapySGRT for setup, DIBH, frameless SRS, motion monitoring, and QA.
TG-307EPID-based IMRT/VMAT QAPre-treatment and transit dosimetry with portal imagers.
MPPG 11.aPlan and chart reviewMinimum prudent physics support for plan/chart review.

Other Safety/QA Numbers

  • TG-218 commonly tested universal IMRT QA gamma: 3%/2 mm, global normalization, absolute dose, 10% threshold, 95% tolerance, 90% action.
  • TG-101 SBRT mindset: steep dose fall-off outside PTV is central to reducing toxicity.
  • MPPG 9.a/9.b SRS/SBRT annual end-to-end dosimetric tolerance for measured vs calculated dose is commonly 5%.
  • TG-203 cardiac implantable device risk: >5 Gy cumulative device dose and neutron-producing beams are high-risk flags.
  • MPPG 11.a cadence language: physics chart review should occur at regular intervals, practically within each block of about 5 treatment fractions, and at clinically meaningful transitions.
  • Small field definition is not simply "less than 10 x 10." Think source occlusion, loss of lateral charged particle equilibrium, and detector size relative to field.

Risk Analysis Language

TermMeaningExam Hook
FMEAProspective failure modes and effects analysisUsed before an event to identify high-risk process steps.
RCARoot-cause analysisReactive; performed after an event or near miss.
Process mapStep-by-step workflow diagramFoundation for FMEA.
Fault treeTop-down analysis of paths leading to failureStarts with undesired event.
Statistical process controlControl charts and process drift detectionMonitors stability over time.
Not FMEA's jobDeciding which workflow steps are nonessentialFMEA scores failures in a defined process; it is not just a lean-process trimming tool.

Dose Reporting and Volumes

  • GTV = visible disease. CTV = microscopic risk. ITV = motion envelope/internal uncertainty. PTV = setup and delivery uncertainty margin. PRV = OAR plus uncertainty.
  • ICRU 83 shifted IMRT reporting away from a single point: use dose-volume reporting such as D98% near-min, D2% near-max, and D50% median dose.
  • Conformity asks "does high dose match target?" Homogeneity asks "how even is target dose?" Gradient asks "how fast does dose fall?"
MetricMeaningFast Interpretation
D98%Dose received by 98% of targetNear-minimum dose.
D2%Dose received by hottest 2% of targetNear-maximum dose.
D50%Median doseRecommended central reporting metric for IMRT-style plans.
V20Volume receiving at least 20 GyDose-volume threshold, common in lung.
D0.03ccSmall-volume maximum-like doseUsed because true point max is unstable.

Dose Algorithms

AlgorithmConceptWhere It Breaks
Pencil beamFast kernel along ray lines.Lung, interfaces, small fields.
Convolution/superpositionModels scatter transport better.Still approximate in extreme heterogeneity.
Collapsed cone / AAAClinical workhorse for photons.Less exact than deterministic/Monte Carlo at interfaces.
Acuros / deterministicSolves transport equation with material assignment.Material mapping and reporting mode matter.
Monte CarloParticle transport simulation.Statistical uncertainty and commissioning burden.

Simulation, Motion, and Registration

  • Changing CT kVp can change the HU-density calibration. mAs mainly changes noise.
  • Aliasing occurs when sampling frequency is less than twice the highest spatial frequency in the object.
  • MIP is useful for bright/high-density moving targets such as many lung nodules; MinIP or phase-by-phase contouring may be needed for hypodense lesions.
  • MRI detects RF signal emitted by relaxing nuclei after excitation, not x-rays.
  • DIBH for breast reduces heart exposure and improves reproducibility, but it requires active patient participation.
  • CBCT is excellent for setup, but it is not continuous beam-on motion monitoring by itself.
  • Beam hardening makes dense structures appear with streak/cupping artifacts; partial-volume averaging blurs small high-contrast structures across voxel boundaries.

4DCT Image Sets

Image SetBest ForTrap
MIPHyperdense/high-contrast moving targets, often lung nodulesCan miss hypodense liver/pancreas lesions.
MinIPHypodense structures/lesions when visibleNot a universal ITV tool.
Average CTDose calculation for many motion-managed plansBlurs anatomy; not always adequate for contouring target extent.
Phase CTMotion review and phase-specific contouringOne phase alone may underrepresent full motion.
Slow CT / free-breathing CTRough motion-inclusive anatomy in some settingsLess explicit than 4DCT for respiratory motion.

Registration and Adaptive Therapy

ConceptMeaningBoard Trap
Rigid registrationTranslation/rotation only.Cannot represent organ deformation or weight-loss anatomy change.
Deformable registrationMaps anatomy with spatially varying deformation vectors.Useful but must be validated; it can create plausible-looking wrong anatomy.
Mutual informationSimilarity metric often used for multimodality registration.Does not require identical image intensity scale.
Online adaptivePlan is adapted for the anatomy of the same treatment session before delivery.Requires expedited contouring, dose calculation, QA, and approval workflow.
Offline adaptiveNew plan is generated from accumulated interval imaging for future fractions.Not delivered in the same session that triggered the change.
MR simulation / MR-linacExcellent soft tissue; dose calculation still needs electron density assignment or synthetic CT.MRI intensity is not HU.

Modulation and Data Flow

  • Inverse planning adjusts beamlet weights to minimize a cost function.
  • Increasing fluence smoothing usually reduces modulation complexity and monitor units.
  • VMAT can modulate MLC position, gantry speed, and dose rate; beam energy and radiation type are not continuously modulated during the arc.
  • DICOM objects contain tags with group/element numbers, value representation, value length, and value field. DICOM-RT moves images/plans/structures, but does not directly control the linac.
  • Machine log files are useful QA data, but they are not themselves standard DICOM radiotherapy objects. RTPLAN, RTSTRUCT, RTDOSE, RTIMAGE, REG, and waveform objects are the safer exam answers.
  • Pre-treatment IMRT QA in a phantom checks deliverability and dose agreement in that QA geometry; it does not prove patient setup, anatomy, collision clearance, or every transfer step.
  • FLASH is usually defined at ultra-high dose rates exceeding about 40 Gy/s.

Source-Strength Formalism

TG-43U1 specifies source strength by air-kerma strength rather than apparent activity. Dose-rate calculation separates source strength, dose-rate constant, geometry, radial dose function, and anisotropy.

TermMeaningBoard Hook
SKAir-kerma strengthUnit U = cGy cm2 h-1.
ΛDose-rate constantConverts source strength to dose rate at reference geometry.
G(r,θ)Geometry factorInverse-square/source-length geometry.
g(r)Radial dose functionAbsorption and scatter along transverse plane.
F(r,θ)AnisotropyAngular variation, self-attenuation, source construction.

TG-43 vs model-based dose calculation: TG-43 assumes water-based conditions and does not fully model patient heterogeneity, applicator shielding, or finite patient scatter. Model-based brachytherapy algorithms address those effects; the reporting trap is to specify whether dose is reported to water or medium.

Source Timing and Dose Rate

ItemNumberUse
Ir-19273.8 d, average energy ~0.38 MeVHDR workhorse; treatment time increases as source decays.
I-12559.4 d, ~28 keVPermanent prostate/eye plaque seeds.
Pd-10317 d, ~21 keVShorter half-life, higher initial dose rate for same total dose.
Cs-13730 y, 662 keVHistorical LDR.
HDR definition>12 Gy/hICRU dose-rate class.
LDR definition0.4-2 Gy/hClassic low dose rate range.
  • HDR treatment time scales inversely with current source strength: tactual = tnominal x Snominal/Sactual.
  • Transit dose grows with number of fractions for the same total prescription because the source travels in and out each fraction.
  • Point A is classically 2 cm superior along the tandem and 2 cm lateral. The modern limitation is obvious: point-based prescription ignores patient anatomy.
  • Well chambers are used for HDR source strength checks; Farmer chambers are not the source-strength tool.
  • HDR source positioning accuracy is a millimeter-level issue, not a casual 3 mm issue. Full calibration language uses +/-1 mm source positioning accuracy.

IORT and Special Brachy Modalities

ModalityTypical TechnologyBoard Hook
Electron IORTMobile/dedicated electron unit, often up to about 12 MeV.Sharp practical range; shielding and applicator alignment dominate setup.
Low-kV IORTMiniature x-ray source around 50 kV.Rapid dose fall-off; high surface/contact dose.
HDR IORTIr-192 afterloader with surface applicator/flap or interstitial catheters.Source path, transfer tubes, dwell positions, and emergency procedures matter.
Electronic brachytherapyElectrically generated low-energy x-rays.No radioactive source decay, but output/source QA still required.

Source QA and Directive Traps

ScenarioKnow ThisExam Trap
HDR written directiveIncludes patient/site, radionuclide, dose, fractionation, and treatment site/volume before treatment.Patient exposure rate for release is not an HDR written directive component.
HDR source strengthMeasured with a well-type ionization chamber and independently checked.Not a Farmer chamber measurement.
HDR interlocks/emergencyCheck door, radiation monitor, applicator/transfer guide tube integrity, emergency retraction, timer.Emergency procedures are not "annual-only" in practical programs; know daily/quarterly/annual categories from TG-56-style QA.
Manual permanent seedsAssay a sample or all sources per institutional/regulatory expectations; compare source strength to vendor certificate.Air-kerma strength is the specified source strength quantity.
Permanent implant follow-upPost-implant evaluation of total source strength outside the treatment site is a 60-day regulatory timing concept.This is separate from the pre-treatment written directive.
Applicator diameterFor same prescription depth, larger cylinder diameter usually lowers mucosal surface dose.Prescription depth fixed does not mean surface dose fixed.
Point AClassically 2 cm superior to flange/fornix along tandem and 2 cm lateral.Point A prescription ignores patient-specific anatomy; modern image-guided brachy uses HR-CTV/OAR DVH metrics.

Barrier Design Logic

QuantityMeaningBoard Default
WWorkloadDose delivered per week at 1 m or isocenter reference.
UUse factorFraction of primary beam directed at barrier.
TOccupancy factorFraction of time a person is in the protected area.
PDesign goalCommon weekly values: uncontrolled 0.02 mSv/wk, controlled 0.1 mSv/wk.
TVLTenth-value layern = log10(1/B) TVLs.
  • Primary barrier: B = P d2/(WUT).
  • Secondary barrier includes leakage and scatter. Leakage workload can be much higher for IMRT; a common board range is C = 2-10 times primary workload.
  • For a 6 MV linac, neutron shielding is not the design driver. Neutrons become a concern for high-energy photon beams above about 10 MV.
  • Use an ion chamber survey meter for photon dose rate beyond a shielded barrier. GM meters are not the right quantitative choice for pulsed therapy barriers.

Shielding Question Pattern

If This Changes...Barrier Thickness DirectionReason
Distance to occupied area increasesDecreasesInverse square reduces required transmission.
Occupancy factor increasesIncreasesMore time in area requires more shielding.
Use factor toward a primary barrier increasesIncreasesMore beam directed at that barrier.
Workload increasesIncreasesMore dose delivered per week.
Area changes from controlled to uncontrolledIncreasesLower public design goal.
Photon energy increasesUsually increasesHigher TVL, and neutrons above high-energy thresholds.

Dose Limits and Regulated Events

Limit / RequirementBoard Number
Adult occupational TEDE50 mSv/y (5 rem/y)
Public dose limit1 mSv/y (0.1 rem/y)
Declared pregnant worker embryo/fetus5 mSv for entire pregnancy, with effort toward uniform monthly exposure.
Individual monitoring thresholdLikely to exceed 10% of applicable limit.
Patient release after radioactive materialTEDE to any other individual not likely to exceed 5 mSv.
Survey meter calibrationBefore first use, annually, and after repair affecting calibration; cannot use if indicated vs calculated exposure rate differs by more than 20%.
NRC medical event notificationNRC telephone notification no later than the next calendar day; written report within 15 days.
Medical event patient notificationNotify referring physician and patient no later than 24 h after discovery, with the regulatory physician-judgment exceptions.
Regulatory scopeNRC regulates byproduct/source material; state programs generally regulate linac x-ray production.
DOT transport indexMaximum radiation level in mrem/h at 1 m from package surface.
  • CTDIvol estimates scanner output for a standardized phantom; DLP = CTDIvol x scan length.
  • Increasing mAs decreases image noise but increases dose roughly linearly.
  • Increasing kVp increases penetration, changes contrast, and can alter HU-density calibration.
  • Tube current modulation reduces unnecessary dose by adjusting mA to patient attenuation.
  • Spatial resolution is about small objects/high spatial frequency; low-contrast resolution is about seeing subtle density differences in noise.
  • MR-linac advantage: soft-tissue visualization and adaptive anatomy assessment. It is not useful because magnetic fields make oxygen molecules radiosensitizers.
Modality / ConceptHigh-Yield PointTrap
CT numberHU = 1000(μ - μwater)/μwaterHU-density table is protocol/energy dependent.
NyquistSampling frequency must be at least twice the highest object spatial frequency.Aliasing occurs when sampling is too low, not too high.
Window/levelWindow = displayed HU range; level = center of range.Display setting does not change underlying image data.
MRI signalRF signal from precessing/relaxing nuclei after excitation.Imaging coil detects emitted RF, not the transmitted RF itself.
Geometric distortion MRIGradient nonlinearity, B0 inhomogeneity, susceptibility, chemical shift.Important for MR simulation and fusion.
PET SUVActivity concentration normalized by injected activity/body habitus.Uptake is not a direct radiation dose measurement.
PET spatial resolutionLimited by detector size, positron range, non-collinearity, depth-of-interaction, and reconstruction.511 keV annihilation photons are emitted nearly, but not perfectly, 180 degrees apart.
CT artifactsBeam hardening, metal streaks, motion, photon starvation, partial volume.Artifacts can corrupt HU-to-density conversion.
SSDESize-specific dose estimate adjusts CTDIvol for patient size.Still an estimate of scanner output/dose, not patient organ dose.

Cram Tables

Radionuclide Snapshot

NuclideHalf-LifeEmission / EnergyUse
Co-605.27 y1.17, 1.33 MeV gamma; avg 1.25 MeVTeletherapy/Gamma Knife historical and current.
Cs-13730.1 y662 keV gammaHistorical LDR.
Ir-19273.8 dAverage ~0.38 MeV gammaHDR/PDR afterloading.
I-12559.4 dLow-energy photons ~28 keVPermanent seeds.
Pd-10317 dLow-energy photons ~21 keVPermanent seeds, faster dose delivery.
Sr-90/Y-9028.8 y / 64 hBetaOphthalmic/surface historical; Y-90 therapy.
Tc-99m6 h140 keV gammaImaging, not therapy.

Question-Type Map

ClusterWhat To MasterTypical Trick
Basics and decaySI units, constants, decay modes, equilibrium, activity math.Unit conversion before formula.
MachinesX-ray tube, filtration, Co-60, linac modes, RF, MLC, FFF.Component that does not change when switching modes.
InteractionsPhotoelectric/Compton/pair, stopping power, neutrons, protons.Energy and material decide the answer.
MeasurementsFluence, kerma, dose, TG-51, detector behavior.Which detector is pressure/temperature/energy dependent?
External beam calcsPDD/TMR, scatter factors, equivalent square, wedges, gaps, heterogeneity.Using the wrong table or forgetting dose per beam.
QA and planningTG-142, TG-218, SRS/SBRT, ICRU 83, motion, DICOM.Protocol number tied to a tolerance.
Brachy/protectionTG-43, air-kerma strength, HDR timing, shielding, NRC release/events.Source strength vs activity; public vs release dose.

Number Snapshot

CategoryNumbers
Constantsc = 3 x 108 m/s; h c = 1240 eV nm; mec2 = 0.511 MeV; 1 amu = 931.5 MeV; proton/electron mass ratio 1836.
Photon interactionsPair threshold 1.022 MeV; Co-60 average 1.25 MeV; Cs-137 662 keV.
DecayT1/2 = 0.693/λ; mean life 1.44 T1/2; 1 Ci = 3.7 x 1010 Bq.
ElectronsR50 ~ E/2.33; Rp ~ E/2; R90 ~ E/3.2.
ProtonsClinical RBE 1.1; 200 MeV range in water about 26 cm; range uncertainty is beam-direction/stopping-power driven.
Linac QADaily output 3%; monthly output 2%; annual calibration 1%; SRS localization mentality 1 mm.
IMRT/SBRTTG-218 3%/2 mm, 95% tolerance, 90% action; SRS/SBRT annual E2E dose agreement often 5%.
BrachyHDR >12 Gy/h; Ir-192 73.8 d; I-125 59.4 d; Pd-103 17 d; HDR source position +/-1 mm; Point A 2 cm up, 2 cm lateral.
ProtectionOccupational 50 mSv/y; public 1 mSv/y; pregnancy embryo/fetus 5 mSv; patient release 5 mSv; survey meter annual/after repair.
EventsNRC medical event phone report by next calendar day; written report 15 d; patient notification generally 24 h after discovery with physician exceptions.

Last-Pass Checklist

  1. What is the quantity? Dose, kerma, exposure, fluence, activity, equivalent dose?
  2. Are the units already compatible? Seconds vs days, MHz vs Hz, cm vs m, cGy vs Gy?
  3. What geometry is implied? SSD/PDD, SAD/TMR, inverse square, field size at collimator vs phantom?
  4. What energy range is implied? kV photoelectric, MV Compton, high-MV neutron, proton distal edge?
  5. What protocol applies? TG-51, TG-142, TG-43, TG-218, NCRP 151, NRC Part 20/35?
  6. Did the question ask for the exception?

Public Source Trail

Mutable protocol and regulatory details were checked against public standards and reference pages. This page is a review aid, not a substitute for the current full reports, institutional policy, or clinical physicist review.