Journal Club & Evidence Appraisal

Papers worth keeping, and the methodological lenses for deciding whether a study should change practice: focused trial reviews in functional neurosurgery alongside the appraisal tools for reading the evidence with appropriate skepticism.

Deep Brain Stimulation Trials

STN vs GPi DBS for Parkinson Disease

Equivalent motor benefit, divergent medication trajectories, and how the randomized trials guide target selection.

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VIM vs PSA DBS for Essential Tremor

The one randomized, blinded trial pitting the thalamus against the territory just beneath it.

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DBS for Treatment-Resistant Depression

Two negative randomized trials that did not settle the question, and why interest persists.

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Focused Ultrasound Trials

Staged Bilateral Focused Ultrasound for Parkinson Disease

Staged bilateral pallidothalamic tractotomy — what the pivotal trial does, and does not, license us to offer.

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Evidence Appraisal

P-values: A Chronic Conundrum

Why statistical significance is not the same thing as true, important, or clinically useful.

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